LITTLE KNOWN FACTS ABOUT ISORHAMNETIN-3-O-GLUCOSIDE.

TAK-243 preferentially certain to UBA1 around the related E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 reduced levels of ubiquitylated proteins, amplified markers of proteotoxic strain and DNA destruction stress. In vivo, TAK-243 lessened leukemic stress and focused leukemic stem cells without having evidence